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Book Folding and Unfolding Mechanism of Designed Ankyrin Repeat Proteins

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Folding and Unfolding Mechanism of Designed Ankyrin Repeat Proteins

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    Available in PDF - DJVU Format | Folding and Unfolding Mechanism of Designed Ankyrin Repeat Proteins.pdf | Language: GERMAN
    Svava Kim Wetzel(Author)

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The ?protein folding problem?, i.e. understanding the detailed stepsof the protein folding pathways is one of the most challenging topicsin biochemistry. Combining theoretical with experimental researchbecame indispensable for the investigation of the mechanisms inprotein folding reactions.Here, the biophysical characterization of designed ankyrin repeat(AR) proteins and the analysis of the experimental data bytheoretical models are presented. Repeat proteins compriserepeating structural units that form linear multirepeat arrays. Thenon-globular elongated structure distinguishes them fundamentallyfrom most studied proteins and makes repeat proteins interestingfor folding studies.In a previous work, a full-consensus ankyrin repeat had beendesigned. Such an idealized ankyrin repeat served as a model repeatto study the folding mechanism of ankyrin repeat proteins.

Svava Kim Wetzel, Dr. sc. nat. : M. sc. in biochemistry/biotechnology at Eberhard- Karls-University Tübingen (D) and Ecole Supérieure de Biotechnologie de Strasbourg(F), PhD studies in protein folding with Prof. A. Plückthun, University of Zurich (CH),Promotion 2008. Postdoc in NMR-spectroscopy with Prof. O. Zerbe, University ofZurich (CH)

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Book details

  • PDF | 104 pages
  • Svava Kim Wetzel(Author)
  • VDM Verlag (6 May 2009)
  • German
  • 4
  • Science & Nature

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